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Monday, August 6

  1. 11:53 pm

Wednesday, July 18

Tuesday, July 17

  1. page Studies in waiting edited ... Cifu DX, Walker WC, West SL, Hart BB, Franke LM, Sima A, Graham CW, Carne W. Hyperbaric oxygen…
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    Cifu DX, Walker WC, West SL, Hart BB, Franke LM, Sima A, Graham CW, Carne W. Hyperbaric oxygen for blast‐related postconcussion syndrome: Three‐month outcomes. Annals of neurology. 2014 Feb 1;75(2):277-86.
    Gallego-Vilar D, García-Fadrique G, Povo-Martin I, Salvador-Marin M, Gallego-Gomez J. Maintenance of the response to dimethyl sulfoxide treatment using hyperbaric oxygen in interstitial cystitis/painful bladder syndrome: a prospective, randomized, comparative study. Urologia internationalis. 2013;90(4):411-6.
    Weaver LK, Wilson SH, Lindblad AS, Churchill S, Deru K, Price RC, Williams CS, Orrison WW, Walker JM, Meehan A, Mirow S. Hyperbaric oxygen for post-concussive symptoms in United States military service members: a randomized clinical trial. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2018;45(2):129-56.
    {home_cmp_copy-of-sumi-painting010_gbtn.gif}
    {Search this web.htm_cmp_copy-of-sumi-painting010_bnr.gif} {Links.htm_cmp_copy-of-sumi-painting010_bnr.gif} {Introduction.htm_cmp_copy-of-sumi-painting010_bnr.gif} {what_is_hyperbaric_medicine.htm_cmp_copy-of-sumi-painting010_bnr.gif}
    (view changes)
    1:03 am

Monday, July 16

  1. page Studies in waiting edited ... Gasier HG, Fothergill DM. Oxidative stress, antioxidant defenses and nitric oxide production f…
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    Gasier HG, Fothergill DM. Oxidative stress, antioxidant defenses and nitric oxide production following hyperoxic exposures. Undersea & hyperbaric medicine: journal of the Undersea and Hyperbaric Medical Society, Inc. 2012 Dec;40(2):125-34.
    Mutzbauer TS, Schneider M, Neubauer B, Weiss M, Tetzlaff K. Antioxidants may Attenuate Plasma Erythropoietin Decline after Hyperbaric Oxygen Diving. International journal of sports medicine. 2015 Nov;36(13):1035-40.
    O'Reilly D, Linden R, Fedorko L, Tarride JE, Jones WG, Bowen JM, Goeree R. A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol.
    Trials. 2011 Mar 7;12:69. doi: 10.1186/1745-6215-12-69.

    Mao M, Rao P, Mou X, Guo L, Zhang L. [Clinical observation on delayed encephalopathy after carbon monoxide poisoning treated with acupuncture to restore consciousness combined with hyperbaric oxygen treatment]. Zhongguo zhen jiu= Chinese acupuncture & moxibustion. 2015 Mar;35(3):213-6.
    Yuan JB, Yang LY, Wang YH, Ding T, Chen TD, Lu Q. Hyperbaric oxygen therapy for recovery of erectile function after posteriorurethral reconstruction. Int Urol Nephrol. 2011 Sep;43(3):755-61. doi: 10.1007/s11255-010-9870-0.
    (view changes)
    11:23 pm
  2. page Non-healing wounds edited ... Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes…
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    Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial.
    Diabetes Care 2016; 39, 392-399.
    Diabetic foot
    Ulcer
    Amputation
    O'Reilly D
    Linden R
    Fedorko L
    A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol.
    Trials. 2011 Mar 7;12:69. doi: 10.1186/1745-6215-12-69

    Diabetic foot
    Ulcer
    (view changes)
    11:21 pm
  3. page Fedorko edited Hyperbaric oxygen therapy did not reduce indications for amputation in patients with diabetic ulcer…
    Hyperbaric oxygen therapy did not reduce indications for amputation in patients with diabetic ulcers
    1. HBOT did not reduce indication for amputation, reduce wound size or improve healing.
    Citation/s: Fedorko
    1.Fedorko
    L, Bowen
    ...
    39, 392-399.
    2. O'Reilly D, Linden R, Fedorko L, Tarride JE, Jones WG, Bowen JM, Goeree R. A prospective, double-blind, randomized, controlled clinical trial comparing standard wound care with adjunctive hyperbaric oxygen therapy (HBOT) to standard wound care only for the treatment of chronic, non-healing ulcers of the lower limb in patients with diabetes mellitus: a study protocol. Trials. 2011 Mar 7;12:69. doi: 10.1186/1745-6215-12-69.

    Lead author's name and email: ludwik.fedorko@uhn.ca
    Three-part Clinical Question: Does hyperbaric oxygen therapy reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb?
    (view changes)
    11:18 pm
  4. page home edited ... Evidence link: to evidence-based review of many HBOT indications (MD thesis of Mike Bennett) …
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    Evidence link: to evidence-based review of many HBOT indications (MD thesis of Mike Bennett)
    Latest CATS:
    ...
    sham treatment (Sampanthavivat 2012).(Fedorko 2016). Dexamethasone might
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    hydradenitis suppurativa Yildiz 2016(Yildiz 2016) and Chiles 2018(Chiles 2018) - HBO
    ...
    syndrome updated Bennett 2015(Bennett 2015)
    {sumhorsa.gif}
    Papers awaiting appraisal: A list of published RCTs we have not got around to yet (take that as an invitation!).
    (view changes)
    11:15 pm
  5. page Fedorko edited ... Appraised by: Katherine Witheridge Department of Diving and Hyperbaric Medicine Prince of Wale…
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    Appraised by: Katherine Witheridge Department of Diving and Hyperbaric Medicine Prince of Wales Hospital ; Monday, 2 July 2018
    Email: katherine.witheridge@health.nsw.gov.au
    ...
    Update By: July 2021
    {sumhorsa.gif}
    BACK

    (view changes)
    11:12 pm
  6. page Non-healing wounds edited ... Including diabetic, vascular and others. {sumhorsa.gif} ... last searched June 2017. Ju…
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    Including diabetic, vascular and others.
    {sumhorsa.gif}
    ...
    last searched June 2017.July 2018. Next search
    Multiple Wound Aetiologies
    Kranke P
    ...
    Effect of hyperbaric oxygen therapy on healing of diabetic foot ulcers.
    J of Foot & Ankle Surgery. 2008;47(6):515-9.
    Diabetic foot
    Ulcer
    Amputation
    Fedorko L
    Bowen JM
    Jones W
    Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial.
    Diabetes Care 2016; 39, 392-399.

    Diabetic foot
    Ulcer
    (view changes)
    11:09 pm
  7. page Fedorko edited Hyperbaric oxygen therapy did not reduce indications for amputation in patients with diabetic ulce…
    Hyperbaric oxygen therapy did not reduce indications for amputation in patients with diabetic ulcers
    1. HBOT did not reduce indication for amputation, reduce wound size or improve healing.
    Citation/s: Fedorko L, Bowen JM, Jones W, Oreopoulos G, Goeree R, Hopkins RB, O’Reilly DJ. Hyperbaric Oxygen Therapy Does Not Reduce Indications for Amputation in Patients With Diabetes With Nonhealing Ulcers of the Lower Limb: A Prospective, Double-Blind, Randomized Controlled Clinical Trial. Diabetes Care 2016; 39, 392-399.
    Lead author's name and email: ludwik.fedorko@uhn.ca
    Three-part Clinical Question: Does hyperbaric oxygen therapy reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb?
    Search Terms: Diabetes, ulcer, chronic wound, wound care, amputation
    The Study: Double-blinded concealed randomised controlled trial with intention-to-treat.
    The Study Patients: Ulcer of the lower limb or foot present for at least 4 weeks
    Control group (N = 54; 54 analysed): Breathing air at 1.3ATA daily for 30 treatments over 6 weeks, plus standard wound care of minimum 2 dressing changes per week
    Experimental group (N = 49; 49 analysed): Breathing 100% O2 at 2.4ATA
    The Evidence:
    Outcome
    Time to Outcome
    Control group rate
    HBO group rate
    Relative risk reduction
    Absolute risk reduction
    NNT
    Adjudicated indication for major or minor amputation (ITT)
    6 weeks
    0.48
    0.51
    4%
    0.01
    111
    95% CIs:
    -43% to 50%
    -0.11 to 0.13
    NNT = 8 to INF; NNH = 9 to INF
    Measure
    Control Group
    HBO Group
    Difference
    95% CI
    Mean
    SD
    Mean
    SD
    Wound measurement (reduction in digital surface area at 12 weeks)
    1.8
    0.42
    1.9
    0.39
    -0.10
    -0.15 to 0.06
    Non-Event Outcomes
    Time to outcome/s
    Control group
    HBO group
    P-value
    Wounds healed
    12 weeks
    12
    10
    0.823
    Comments:
    1. Underpowered based on an estimated sample size of 118 patients. The methods used to determine sample size or expected event rates are unclear.
    2. Only 87 patients analysed as per protocol (had completed at least 27 treatments or healed before protocol end). Intention to treat analysis captured only 103 patients.
    3. There was a change in outcome assessment from examination by a vascular surgeon to assessment of clinical notes and photographs between the ethics protocol and the published paper. This method of assessment does not seem to have been validated.
    4. Very short outcomes at only 12 weeks from first treatment session.
    5. Some baseline differences between groups may have biased the outcome.
    6. No attempt to demonstrate hypoxia as is usual in patient selection for treatment.
    7. Trans-metatarsal amputation was included in the definition of ‘major amputation’ which is unusual.
    8. No clear rationale for excluding patients who had undergone revascularisation in the previous 3 months.
    Appraised by: Katherine Witheridge Department of Diving and Hyperbaric Medicine Prince of Wales Hospital ; Monday, 2 July 2018
    Email: katherine.witheridge@health.nsw.gov.au
    Kill or Update By:

    (view changes)
    11:05 pm

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