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Monday, February 12

  1. page Studies in waiting edited ... Naiboğllu B, Külekçi S, Sürmeli M, Verim A, Kalaycik EÇ, İhvan Ö, Şeneldir L, Zer TS. Efficacy…
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    Naiboğllu B, Külekçi S, Sürmeli M, Verim A, Kalaycik EÇ, İhvan Ö, Şeneldir L, Zer TS. Efficacy of multimodality approach to sudden hearing loss. Kulak burun bogaz ihtisas dergisi: KBB= Journal of ear, nose, and throat. 2014 Dec;25(2):77-81.
    Shimoda M, Enomoto M, Horie M, Miyakawa S, Yagishita K. Effects of hyperbaric oxygen on muscle fatigue after maximal intermittent plantar flexion exercise. The Journal of Strength & Conditioning Research. 2015 Jun 1;29(6):1648-56.
    Hsu SL, Wang CJ, Lee MS, Chan YS, Huang CC, Yang KD. Cocktail therapy for femoral head necrosis of the hip.Arch Orthop Trauma Surg. 2010 Jan;130(1):23-9. doi: 10.1007/s00402-009-0918-5.
    Blatteau JE, Pontier JM. Effect of in-water recompression with oxygen to 6 msw versus normobaric oxygenbreathing on bubble formation in divers. Eur J Appl Physiol. 2009 Jul;106(5):691-5. doi: 10.1007/s00421-009-1065-y. Epub2009 May 8.
    Rasmussen VM, Borgen AE, Jansen EC, Rotbøll Nielsen PH, Werner MU. Hyperbaric oxygen therapy attenuates central sensitization induced by a thermal injury in humans. Acta Anaesthesiologica Scandinavica. 2015 Jul 1;59(6):749-62.
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  2. page home edited ... Evidence link: to evidence-based review of many HBOT indications (MD thesis of Mike Bennett) …
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    Evidence link: to evidence-based review of many HBOT indications (MD thesis of Mike Bennett)
    Latest CATS:
    ...
    no) AND Duzgun 2008Hsu 2010 - More evidence to support the tretamentHBO and Alendronate with ESWT did not produce better results than ESWT alone for avascular necrosis of diabetic foot ulcersthe femoral head
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    Papers awaiting appraisal: A list of published RCTs we have not got around to yet (take that as an invitation!).
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  3. page Fractures edited ... The use of HBOT for the treatment of bone injuries and necrosis not due to radiation therapy. …
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    The use of HBOT for the treatment of bone injuries and necrosis not due to radiation therapy.
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    Next search October 2017February 2021
    Author 1
    Author 2
    ...
    Freiberger JJ
    Padilla-Burgos R.
    ...
    taken bisphosphonates.
    Undersea and Hyperbaric Medicine 2007;34(4):241
    Bisphosphonate
    ...
    Caberti L
    Cantadori L
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    randomized trial.
    Undersea and Hyperbaric Medicine 2005; 32(4):272-273.
    Avascular necrosis
    ...
    Hyperbaric oxygen therapy in femoral head necrosis.
    Journal of Arthroplasty 2010;25(6):118-123
    Avascular necrosis
    Idiopathic
    Hsu SL
    Wang CJ
    Lee MS
    Cocktail therapy for femoral head necrosis of the hip.
    Arch Orthop Trauma Surg. 2010 Jan;130(1):23-9

    Avascular necrosis
    Idiopathic
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  4. page Bennett5 edited ... No trials met the inclusion criteria. We excluded one trial that compared HBOT with no treatme…
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    No trials met the inclusion criteria. We excluded one trial that compared HBOT with no treatment because no clinical outcomes were reported.
    Reviewers' conclusions
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    these injuries.
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    BACK
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  5. page Freiberger edited ... 3. Lack of blinding with sham therapy may be a future criticism Appraised by: Mike Bennett, S…
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    3. Lack of blinding with sham therapy may be a future criticism
    Appraised by: Mike Bennett, Sydney ; Thursday, 6 December 2007Email: m.bennett@unsw.edu.au
    ...
    Update By: December 2008
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    February 2021
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    BACK
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  6. page Camporesi edited ... 3. Clinical significance is unclear, but probable true functional improvement for this group. …
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    3. Clinical significance is unclear, but probable true functional improvement for this group.
    Appraised by: Mike Bennett m.bennett@unsw.edu.au ;Monday 9th October 2017
    ...
    Update By: October 2020February 2021
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  7. page Hsu edited A cocktail treatment including hyperbaric oxygen and alendronate was not more effective than ext…

    A cocktail treatment including hyperbaric oxygen and alendronate was not more effective than extracorporeal shockwave treatment alone for the treatment of femoral head necrosis.
    1. The addition of hyperbaric oxygen and alendronate did not improve outcome over EWST alone.
    Citation/s:
    1. Hsu SL, Wang CJ, Lee MS, Chan YS, Huang CC, Yang KD. Cocktail therapy for femoral head necrosis of the hip.Arch Orthop Trauma Surg. 2010 Jan;130(1):23-9.
    Lead author's name and fax: Shan-Ling Hsu w281211@adm.cgmh.org.tw
    Three-part Clinical Question: For patient with femoral head necrosis, does the addition of hyperbaric oxygen and alendronate to treatment with extracorporeal shockwave treatment (ESWT), result in any improvement in outcome?
    Search Terms: ESWT, alendronate, femoral necrosis
    The Study: Non-blinded pseudo-randomised trial without intention-to-treat.
    The Study Patients: Adult patients with stage I, II or III femoral hip necrosis according to the ARCO classification
    Control group (N = 48; 48 analysed): Patients received a session of ESWT under general anaesthesia with the target area identified by mobile X-Ray fluorosopy. 6,000 shocks in total at 28kV.
    Experimental group (N = 50; 50 analysed): As above plus 100% oxygen at 2.5 ATA for 50 minutes daily to a total of 20 treatments, and 70mg alendronate weekly for 12 months
    The Evidence:
    Outcome
    Time to Outcome
    ESWT group
    Cocktail group
    Relative risk reduction
    Absolute risk reduction
    NNT
    Total hip replacement
    24 months
    0.104
    0.100
    4%
    0.004
    250
    95% CIs:
    -111% to 100%
    -0.116 to 0.124
    NNT = 8 to INF; NNH = 9 to INF
    Improved symptoms
    24 months
    0.792
    0.740
    7%
    0.052
    19
    95% CIs:
    -15% to 28%
    -0.115 to 0.219
    NNT = 5 to INF; NNH = 9 to INF
    Decrease in size of MRI lesion
    after treatment
    0.208
    0.22
    -6%
    -0.012
    -83
    95% CIs:
    -84% to 72%
    -0.174 to 0.150
    NNT = 7 to INF; NNH = 6 to INF
    Measure
    ESWT Group
    Cocktail Group
    Difference
    95% CI
    Mean
    SD
    Mean
    SD
    Activities of daily living (SF12) after treatment
    47.6
    7.1
    44.3
    6.9
    3.35
    0.53 to 6.17
    Pain score at end of treatment
    1.1
    1.5
    1.5
    1.3
    -0.40
    -0.96 to 0.16
    Comments:
    1. This was a pseudorandomised, unblinded trial that was not analysed by intention to treat. Allocation was by record number and there were a total seven hips replaced (5 in cocktal group and 2 in ESWT group) that were excluded.
    2. The stated primary outcome was total hip replacement, but this is not prominently presented in results.
    3. The authors’ note that more success was obtained for those with lower grade lesions as would be expected.
    4. Many of the outcomes measures are not explained in this paper.
    5. All analyses are made by hip rather than patient (50 hips in 28 patients in cocktail group and 48 hips in 35 patients in ESWT group). This might favour the EWST group as more patients had single side disease.
    Appraised by: Mike Bennett; Monday, 12 February 2018
    Email: m.bennett@unsw.edu.au
    Kill or Update By: February 2021

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